Natural Products Mediate Cross-Kingdom Interactions

Since the development of microbes and higher eukaryotes coevolution has resulted in specific interaction mechanisms. It is well known that symbiotic bacteria and fungi influence the life cycle, and are essential for the homeostasis of many eukaryotes. However, in most cases, the factors driving and influencing the cross-kingdom interactions are unknown.

We focus on the structural identification of microbial chemical mediators that are important to maintain the symbiotic life style of the producing organisms. To study the chemical signals we apply state-of-the-art analytical tools: Analytical Chemistry (UHPLC, UHPLC-MS, NMR, MALDI etc.), Genome Mining and Molecular Biology and Organic Synthesis (total synthesis and natural product derivatization)